Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | FABP7 | O15540 | 1/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12295621 | 0.87 | HDAC1 (0.49) | KDM4EKMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL4652078 | 0.83 | MAPT (0.46) | MAPTKDM4EKMT2AFABP7FABP5 | |
| SCHEMBL22397770 | 0.82 | POLB (0.52) | MAPTPOLBKMT2AMEN1FABP7 | |
| SCHEMBL13327274 | 0.82 | POLB (0.52) | MAPTPOLBKMT2AMEN1FABP7 | |
| SCHEMBL9883398 | 0.81 | KMT2A (0.44) | POLBKDM4EKMT2AALDH1A1TSHR | |
| SCHEMBL15344316 | 0.80 | HDAC1 (0.55) | POLBPTPN11SLC6A7KMT2AMEN1 | |
| SCHEMBL3219970 | 0.79 | FABP5 (0.49) | MAPTPOLBKMT2AFABP7FABP5 | |
| SCHEMBL12295654 | 0.78 | MAPT (0.39) | MAPTPOLBPTPN11KDM4EALDH1A1 | |
| SCHEMBL1919757 | 0.78 | MAPT (0.43) | MAPTPOLBPTPN11KDM4EKMT2A | |
| SCHEMBL25417781 | 0.77 | MAPT (0.38) | MAPTPOLBKDM4ESLC6A7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426416-B2 | Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2013-04-23 | — | — | US | disclosed |
| US-8426416-B2 | Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2013-04-23 | — | — | US | disclosed |
| US-20110237585-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-09-29 | — | — | US | disclosed |
| US-20110237585-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-09-29 | — | — | US | disclosed |
| US-7947830-B2 | Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-05-24 | — | — | US | disclosed |
| US-7947830-B2 | Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-05-24 | — | — | US | disclosed |
| US-7888360-B2 | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-02-15 | — | — | US | disclosed |
| US-7888360-B2 | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-02-15 | — | — | US | disclosed |
| US-7884105-B2 | 2-(N'-2-amino-3,4-dioxocyclobutenyl)-N-piperazinyl)-pyrimidine-5-hydroxamic acid derivatives; antiproliferative, anticarcinogenic, and antitumor agents; psoriasis; skin, respiratory system, psychological, and genetic disorders; transplant rejection; Alzheimer's and Parkinson's disease; vision defects | JANSSEN PHARMACEUTICA, N.V. (BE) | 2011-02-08 | — | — | US | disclosed |
| US-7884105-B2 | 2-(N'-2-amino-3,4-dioxocyclobutenyl)-N-piperazinyl)-pyrimidine-5-hydroxamic acid derivatives; antiproliferative, anticarcinogenic, and antitumor agents; psoriasis; skin, respiratory system, psychological, and genetic disorders; transplant rejection; Alzheimer's and Parkinson's disease; vision defects | JANSSEN PHARMACEUTICA, N.V. (BE) | 2011-02-08 | — | — | US | disclosed |
| US-20090036463-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-02-05 | — | — | US | disclosed |
| US-20090036463-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-02-05 | — | — | US | disclosed |
| US-20080255140-A1 | Squaric Acid Derivatives as Inhibitors of Histone Deacetylase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-10-16 | — | — | US | disclosed |
| US-20080255140-A1 | Squaric Acid Derivatives as Inhibitors of Histone Deacetylase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-10-16 | — | — | US | disclosed |
| US-20070135424-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN-CILAG (BE) | 2007-06-14 | — | — | US | disclosed |
| US-20070135424-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN-CILAG (BE) | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036463-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC3 | MAPT 3260/4885POLB 325/4885PTPN11 3323/4885 |
| US-20080255140-A1 | Squaric Acid Derivatives as Inhibitors of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | MAPT 3262/4885POLB 902/4885PTPN11 4268/4885 |
| US-20070135424-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | MAPT 3052/4885POLB 504/4885PTPN11 3770/4885 |
| US-20110237585-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | MAPT 3052/4885POLB 504/4885PTPN11 3770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.