Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.34 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12295616 | 0.90 | HDAC1 (0.45) | ALDH1A1KDM4EHDAC1P2RY12HPGD | |
| SCHEMBL9883402 | 0.87 | CHRM4 (0.38) | P2RX3DGAT2HDAC1GSTP1GSTM2 | |
| SCHEMBL15344312 | 0.86 | HDAC1 (0.48) | PTPN11HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL10097871 | 0.81 | HDAC3 (0.47) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL15341328 | 0.80 | KDM4E (0.42) | MAPTALDH1A1TSHRKDM4EHSD17B10 | |
| SCHEMBL5503694 | 0.79 | ALDH1A1 (0.40) | PTPN11ALDH1A1TSHRKDM4EHSD17B10 | |
| SCHEMBL17897327 | 0.79 | KMT2A (0.38) | P2RX3TGFBR1POLBGSTP1GSTM2 | |
| SCHEMBL13535015 | 0.79 | KDM4E (0.42) | PTPN11ALDH1A1TSHRKDM4EHSD17B10 | |
| SCHEMBL12295653 | 0.78 | MAPT (0.46) | MAPTPTPN11ALDH1A1TSHRKDM4E | |
| SCHEMBL15341327 | 0.78 | ALDH1A1 (0.42) | MAPTPTPN11ALDH1A1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426416-B2 | Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2013-04-23 | — | — | US | disclosed |
| US-20110237585-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-09-29 | — | — | US | disclosed |
| US-7947830-B2 | Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-05-24 | — | — | US | disclosed |
| US-7947830-B2 | Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-05-24 | — | — | US | disclosed |
| US-7888360-B2 | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-02-15 | — | — | US | disclosed |
| US-7884105-B2 | 2-(N'-2-amino-3,4-dioxocyclobutenyl)-N-piperazinyl)-pyrimidine-5-hydroxamic acid derivatives; antiproliferative, anticarcinogenic, and antitumor agents; psoriasis; skin, respiratory system, psychological, and genetic disorders; transplant rejection; Alzheimer's and Parkinson's disease; vision defects | JANSSEN PHARMACEUTICA, N.V. (BE) | 2011-02-08 | — | — | US | disclosed |
| US-20090036463-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-02-05 | — | — | US | disclosed |
| US-20080255140-A1 | Squaric Acid Derivatives as Inhibitors of Histone Deacetylase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-10-16 | — | — | US | disclosed |
| US-20070135424-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN-CILAG (BE) | 2007-06-14 | — | — | US | disclosed |
| US-20070135424-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN-CILAG (BE) | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036463-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC3 | MAPT 3260/4885PTPN11 3323/4885ALDH1A1 517/4885 |
| US-20080255140-A1 | Squaric Acid Derivatives as Inhibitors of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | MAPT 3262/4885PTPN11 4268/4885ALDH1A1 239/4885 |
| US-20070135424-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | MAPT 3052/4885PTPN11 3770/4885ALDH1A1 399/4885 |
| US-20110237585-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | MAPT 3052/4885PTPN11 3770/4885ALDH1A1 399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.