Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.41 |
| ▸ | ITGAL | P20701 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14872323 | 1.00 | DPP4 (0.44) | DPP4DPP9HRH4ITGB2ICAM1 | |
| SCHEMBL14872316 | 1.00 | DPP4 (0.44) | DPP4DPP9HRH4ITGB2ICAM1 | |
| SCHEMBL11981591 | 0.90 | SMO (0.46) | HRH4ITGB2ICAM1ITGALJAK2 | |
| SCHEMBL11981511 | 0.86 | EGLN2 (0.40) | HRH4LRRK2HRH3CYP17A1 | |
| SCHEMBL14868458 | 0.80 | ITGB2 (0.45) | DPP4DPP9HRH4ITGB2ICAM1 | |
| SCHEMBL14868472 | 0.80 | ITGB2 (0.45) | DPP4DPP9HRH4ITGB2ICAM1 | |
| SCHEMBL14868421 | 0.80 | ITGB2 (0.45) | DPP4DPP9HRH4ITGB2ICAM1 | |
| SCHEMBL15114895 | 0.78 | LMNA (0.49) | HRH4LMNAHTT | |
| SCHEMBL22873583 | 0.77 | HRH4 (0.47) | HRH4LRRK2HRH3PRKDCLMNA | |
| SCHEMBL22873765 | 0.77 | HRH4 (0.47) | HRH4LRRK2HRH3PRKDCLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130096104-A1 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2013-04-18 | — | — | US | disclosed |
| WO-2011113802-A2 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096104-A1 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | TYK2, IRAK1, IRAK4 | DPP4 3139/4885DPP9 3611/4885HRH4 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.