SCHEMBL1229680

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1231319	0.88	JAK2 (0.46)	JAK2JAK1TYK2ROCK1ROCK2
	SCHEMBL1230522	0.88	IKBKB (0.46)	JAK2JAK1TYK2ROCK1ROCK2
	SCHEMBL13517118	0.85	JAK2 (0.41)	JAK2JAK1TYK2ROCK1ROCK2
	SCHEMBL1231735	0.84	ROCK1 (0.41)	ROCK1ROCK2PRKD3PRKACAPRKCQ
	SCHEMBL1231358	0.84	JAK2 (0.38)	JAK2JAK1TYK2ROCK1ROCK2
	SCHEMBL1230543	0.83	PTPRC (0.41)	JAK2JAK1TYK2ROCK1BMPR1A
	SCHEMBL1229684	0.82	ALDH1A1 (0.40)	JAK2JAK1TYK2ROCK1ROCK2
	SCHEMBL19390351	0.82	ADORA2A (0.45)	JAK2JAK1TYK2ROCK1PKN2
	SCHEMBL13517059	0.82	ADORA2A (0.43)	JAK2JAK1TYK2ROCK1PKN2
	SCHEMBL12901040	0.81	AKT1 (0.50)	JAK2JAK1TYK2ROCK1ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.