Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 5/20 | 0.45 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.45 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | P2RY10 | O00398 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12301288 | 1.00 | LPAR3 (0.45) | LPAR3LPAR1LPAR2GAAP2RY10 | |
| SCHEMBL12301290 | 1.00 | LPAR3 (0.45) | LPAR3LPAR1LPAR2GAAP2RY10 | |
| SCHEMBL12301292 | 1.00 | LPAR3 (0.45) | LPAR3LPAR1LPAR2GAAP2RY10 | |
| SCHEMBL9238036 | 0.89 | LPAR3 (0.56) | LPAR3LPAR1LPAR2RARB | |
| SCHEMBL28654699 | 0.88 | MEN1 (0.47) | LPAR3LPAR1LPAR2GAAP2RY10 | |
| SCHEMBL28659099 | 0.88 | MEN1 (0.47) | LPAR3LPAR1LPAR2GAAP2RY10 | |
| SCHEMBL28655408 | 0.88 | MEN1 (0.47) | LPAR3LPAR1LPAR2GAAP2RY10 | |
| SCHEMBL28678711 | 0.88 | MEN1 (0.47) | LPAR3LPAR1LPAR2GAAP2RY10 | |
| SCHEMBL28670535 | 0.86 | MEN1 (0.48) | LPAR3LPAR1LPAR2GAAP2RY10 | |
| SCHEMBL3671797 | 0.83 | LPAR3 (0.50) | LPAR3LPAR1LPAR2RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022239-B2 | Mechanism-based inactivators of autotaxin | THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION (US) | 2011-09-20 | — | — | US | disclosed |
| US-20100136650-A1 | MECHANISM-BASED INACTIVATORS OF AUTOTAXIN | THE UNIVERSITY OF MEMPHIS | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100136650-A1 | MECHANISM-BASED INACTIVATORS OF AUTOTAXIN | ENPP2, PLA2G12A, PLA2G10 | LPAR3 77/4885LPAR1 93/4885LPAR2 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.