Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.40 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2385364 | 0.95 | CCR2 (0.41) | TRPV1NR2E1CCR2KCNH2KIT | |
| SCHEMBL12302305 | 0.85 | TRPV1 (0.42) | TRPV1NR2E1MEN1KMT2AP2RY12 | |
| SCHEMBL2385128 | 0.85 | PAK1 (0.43) | TRPV1NR2E1KITPAK1MAPT | |
| SCHEMBL12302306 | 0.80 | TRPV1 (0.44) | TRPV1NR2E1MEN1KMT2AALDH1A1 | |
| SCHEMBL2384156 | 0.80 | TRPV1 (0.43) | TRPV1NR2E1KITPAK1MAPT | |
| SCHEMBL2384579 | 0.79 | IDH2 (0.44) | TRPV1MEN1KMT2AALDH1A1PAK1 | |
| SCHEMBL2382905 | 0.76 | TRPV1 (0.46) | TRPV1NR2E1KITPAK1MAPT | |
| SCHEMBL2382791 | 0.74 | TRPV1 (0.43) | TRPV1KITMAPTLMNAGAA | |
| SCHEMBL2382932 | 0.74 | TRPV1 (0.42) | TRPV1NR2E1KMT2APAK1MAPT | |
| SCHEMBL12302867 | 0.72 | TRPV1 (0.43) | TRPV1NR2E1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013156-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | disclosed |