Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2452131 | 0.95 | APP (0.41) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL12167426 | 0.95 | APP (0.41) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL5283637 | 0.91 | HRH2 (0.40) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL1750578 | 0.91 | HRH2 (0.40) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL2451888 | 0.90 | ALOX5AP (0.38) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL12303253 | 0.90 | ALOX5AP (0.38) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL2449390 | 0.88 | APP (0.42) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL12303250 | 0.88 | APP (0.42) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL12303252 | 0.87 | HRH2 (0.43) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL2452127 | 0.87 | HRH2 (0.43) | APPHTR1AADRA2ADRD2ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920093-B2 | Dimeric IAP inhibitors | TetraLogic Birinapant UK Ltd. (GB) | 2018-03-20 | — | — | US | disclosed |
| US-9920093-B2 | Dimeric IAP inhibitors | TetraLogic Birinapant UK Ltd. (GB) | 2018-03-20 | — | — | US | disclosed |
| US-20160355547-A1 | Dimeric IAP Inhibitors | TETRALOGIC BIRINAPANT UK LTD (GB) | 2016-12-08 | — | — | US | disclosed |
| US-20160355547-A1 | Dimeric IAP Inhibitors | TETRALOGIC BIRINAPANT UK LTD (GB) | 2016-12-08 | — | — | US | disclosed |
| US-9187490-B2 | Dimeric IAP inhibitors | TetraLogic Birinapant UK Ltd. (GB) | 2015-11-17 | — | — | US | disclosed |
| US-9187490-B2 | Dimeric IAP inhibitors | TetraLogic Birinapant UK Ltd. (GB) | 2015-11-17 | — | — | US | disclosed |
| US-20140329823-A1 | Dimeric IAP Inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2014-11-06 | — | — | US | disclosed |
| US-20140329823-A1 | Dimeric IAP Inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2014-11-06 | — | — | US | disclosed |
| US-8822525-B2 | Dimeric IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2014-09-02 | — | — | US | disclosed |
| US-8822525-B2 | Dimeric IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2014-09-02 | — | — | US | disclosed |
| US-8497297-B2 | Dimeric IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2013-07-30 | — | — | US | disclosed |
| US-8497297-B2 | Dimeric IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2013-07-30 | — | — | US | disclosed |
| US-20110301151-A1 | DIMERIC IAP INHIBITORS | TETRALOGIC PHARMACEUTICALS CORPORATION | 2011-12-08 | — | — | US | disclosed |
| US-20110301151-A1 | DIMERIC IAP INHIBITORS | TETRALOGIC PHARMACEUTICALS CORPORATION | 2011-12-08 | — | — | US | disclosed |
| US-8022230-B2 | Dimeric IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2011-09-20 | — | — | US | disclosed |
| US-8022230-B2 | Dimeric IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2011-09-20 | — | — | US | disclosed |
| US-20100075911-A1 | DIMERIC IAP INHIBITORS | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075911-A1 | DIMERIC IAP INHIBITORS | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2010-03-25 | — | — | US | disclosed |
| US-7517906-B2 | Dimeric IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2009-04-14 | — | — | US | disclosed |
| US-7517906-B2 | Dimeric IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2009-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075911-A1 | DIMERIC IAP INHIBITORS | BIRC2, XIAP, BIRC5 | APP 1148/4885HTR1A 1567/4885ADRA2A 4711/4885 |
| US-20110301151-A1 | DIMERIC IAP INHIBITORS | BIRC2, XIAP, BIRC5 | APP 1148/4885HTR1A 1567/4885ADRA2A 4711/4885 |
| US-20140329823-A1 | Dimeric IAP Inhibitors | BIRC2, XIAP, BIRC5 | APP 1148/4885HTR1A 1567/4885ADRA2A 4711/4885 |
| US-20160355547-A1 | Dimeric IAP Inhibitors | BIRC2, XIAP, BIRC5 | APP 1148/4885HTR1A 1567/4885ADRA2A 4711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.