Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 7/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750578 | 1.00 | HRH2 (0.40) | HRH2APPHTR1AADRA2ADRD2 | |
| SCHEMBL12303255 | 0.91 | APP (0.42) | HRH2APPHTR1AADRA2ADRD2 | |
| SCHEMBL2452131 | 0.88 | APP (0.41) | HRH2APPHTR1AADRA2ADRD2 | |
| SCHEMBL12167426 | 0.88 | APP (0.41) | HRH2APPHTR1AADRA2ADRD2 | |
| SCHEMBL12303253 | 0.86 | ALOX5AP (0.38) | HRH2APPHTR1AADRA2ADRD2 | |
| SCHEMBL2451888 | 0.86 | ALOX5AP (0.38) | HRH2APPHTR1AADRA2ADRD2 | |
| SCHEMBL12529635 | 0.85 | TNF (0.39) | HRH2CNR1CNR2 | |
| SCHEMBL1752573 | 0.85 | TNF (0.39) | HRH2CNR1CNR2 | |
| SCHEMBL12303252 | 0.83 | HRH2 (0.43) | HRH2APPHTR1AADRA2ADRD2 | |
| SCHEMBL2452127 | 0.83 | HRH2 (0.43) | HRH2APPHTR1AADRA2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773766-A2 | IAP BINDING COMPOUNDS | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006020060-A2 | IAP BINDING COMPOUNDS | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |