⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744233 | 0.81 | — | — | |
| SCHEMBL14737710 | 0.81 | — | — | |
| SCHEMBL29192982 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL20659484 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL29821508 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL20659482 | 0.77 | — | — | |
| SCHEMBL6052759 | 0.73 | — | — | |
| SCHEMBL25330340 | 0.69 | SLC22A2 (0.35) | — | |
| SCHEMBL511273 | 0.69 | — | — | |
| SCHEMBL635168 | 0.69 | ROCK2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4370136-A2 | SIMPLE CHEMICAL APPROACHES TO INTRODUCE 2,6-DIAMINOPURINE AND 2-AMINOADENINE CONJUGATES INTO OLIGONUCLEOTIDES | Alnylam Pharmaceuticals, Inc. (US) | 2024-05-22 | — | — | EP | disclosed |
| WO-2023288045-A2 | SIMPLE CHEMICAL APPROACHES TO INTRODUCE 2,6-DIAMINOPURINE AND 2-AMINOADENINE CONJUGATES INTO OLIGONUCLEOTIDES | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-01-19 | — | — | WO | disclosed |
| EP-3934700-A1 | NON-ACTIVE LIPID NANOPARTICLES WITH NON-VIRAL, CAPSID FREE DNA | Generation Bio Co. (US) | 2022-01-12 | — | — | EP | disclosed |
| WO-2018136620-A2 | ENDOSOMAL CLEAVABLE LINKERS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2018-07-26 | — | — | WO | disclosed |
| WO-2015112809-A2 | NSD3 INHIBITORS FOR TREATMENT OF CANCERS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2015-07-30 | — | — | WO | disclosed |
| WO-2013188787-A1 | INHIBITORS OF MICRORNAs THAT REGULATE PRODUCTION OF ATRIAL NATRIURETIC PEPTIDE (ANP) AS THERAPEUTICS AND USES THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2013-12-19 | — | — | WO | disclosed |
| WO-2011017137-A2 | METHODS AND COMPOSITIONS FOR TREATING INSECTS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | disclosed |