Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 1.00 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL21815132 | 1.00 | CA4 (1.00) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL29094234 | 1.00 | CA4 (1.00) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL30697337 | 1.00 | CA4 (1.00) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL7573233 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL22797824 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL5515454 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL163976 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL2711210 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL5515456 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL7574684 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8186 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4158079-B1 | GOLD PLATING BATH AND GOLD PLATED FINAL FINISH | MACDERMID ENTHONE INC (US) | 2026-05-27 | — | — | EP | claimed |
| EP-3691647-B1 | NEW TREATMENT OF SMA | HOFFMANN LA ROCHE (CH) | 2026-05-27 | — | — | EP | claimed |
| CN-122091626-A | Metal bipolar plate, preparation method thereof and fuel cell | — | 2026-05-26 | — | — | CN | claimed |
| CN-122074634-A | Shungangda stomach-protecting seasoning product | — | 2026-05-26 | — | — | CN | claimed |
| EP-3785708-B1 | FILM-FORMING COMPOSITION CONTAINING SURFACTANT OR SURFACTANT AND SALT AS WHITENING AGENT | CAPSUGEL BELGIUM NV (BE) | 2026-05-20 | — | — | EP | claimed |
| CN-118479451-B | Method for synthesizing carbon cathode material of sodium battery in ultrafast way | 上海交通大学绍兴新能源与分子工程研究院 | 2026-05-19 | — | — | CN | claimed |
| CN-122039492-A | Cigarette paper coloring agent and preparation method thereof | 杭州市实业投资集团有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122031379-A | Fluorine Lei Lana-moxidectin nano drop containing penetration enhancer and preparation method thereof | 广州白云山宝神动物保健品有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122039148-A | Composite electrolytic water catalyst based on coal gangue carbon residue substrate and ligand intercalated layered double hydroxide and preparation method thereof | 安徽理工大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122030282-A | Pig heat stress resistant composite device based on environment enrichment and preparation method thereof | 东北农业大学 | 2026-05-15 | — | — | CN | claimed |
| EP-0153307-A1 | USE OF SELENIUM-CONTAINING COMPOUNDS FOR NEGATING THE TOXIC EFFECTS OF GOLD COMPOUNDS USED IN THE TREATMENT OF RHEUMATOID ARTHRITIS, AND A NOVEL SELENIUM-CONTAINING GOLD COMPOUND AND USE THEREOF AS AN ANTI-RHEUMATOID ARTHRITIS MEDICINE | STOCKEL, Richard F. (US) | 1985-09-04 | — | — | EP | claimed |
| US-4506684-A | PRECIPITATION OF METAL SALTS | PHILIP MORRIS INCORPORATED (US) | 1985-03-26 | — | — | US | claimed |
| WO-1985000747-A1 | USE OF SELENIUM-CONTAINING COMPOUNDS FOR NEGATING THE TOXIC EFFECTS OF GOLD COMPOUNDS USED IN THE TREATMENT OF RHEUMATOID ARTHRITIS, AND A NOVEL SELENIUM-CONTAINING GOLD COMPOUND AND USE THEREOF AS AN ANTI-RHEUMATOID ARTHRITIS MEDICINE | STOCKEL RICHARD F | 1985-02-28 | — | — | WO | claimed |
| US-4406882-A | GLYCYRRHETINIC ACID, ESTER DERIVATIVES | BIOREX LABORATORIES LIMITED (GB) | 1983-09-27 | — | — | US | claimed |
| US-4231890-A | COMPRISING A PEROXIDE, NITRILOTRIACETIC ACID AS STABILIZER FOR THE PEROXIDE, AND WATER SOFTENER | KAO SOAP CO., LTD. (JP) | 1980-11-04 | — | — | US | claimed |
| US-4213918-A | Process for producing clear aqueous solution of olefin sulfonic acid | THE LION FAT & OIL CO., LTD. (JP) | 1980-07-22 | — | — | US | claimed |
| US-4029606-A | ACYL-POLYHYDROXY CARBOXYLATE | LION FAT & OIL CO., LTD. (JA) | 1977-06-14 | — | — | US | claimed |
| US-4013416-A | Diagnostic means for the detection of protein in body fluids | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1977-03-22 | — | — | US | claimed |
| US-3971703-A | Method of detecting and counting bacteria | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1976-07-27 | — | — | US | claimed |
| US-3930896-A | NICKEL-COBALT ALLOY | TATSUTA DENSEN KABUSHIKI KAISHA (JA) | 1976-01-06 | — | — | US | claimed |