Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 1.00 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL21815132 | 1.00 | CA4 (1.00) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL29094234 | 1.00 | CA4 (1.00) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL123089 | 1.00 | CA4 (1.00) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL7573233 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL22797824 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL5515454 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL163976 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL2711210 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL5515456 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL7574684 | 0.97 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024092045-A1 | PLATINUM(II)-BASED ANTICANCER AGENTS, TARGETED CONJUGATES, AND METHOD OF SYNTHESIZING THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2024-05-02 | — | — | WO | disclosed |
| CN-117247932-A | Method for improving utilization rate of cap analogues in-vitro transcription | 南京诺唯赞生物科技股份有限公司 | 2023-12-19 | — | — | CN | disclosed |