Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL3408017 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL28831630 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL637799 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL3408016 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL16150600 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL7573228 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL17135308 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL10943339 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL10943344 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL9478602 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7585 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4158079-B1 | GOLD PLATING BATH AND GOLD PLATED FINAL FINISH | MACDERMID ENTHONE INC (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122074634-A | Shungangda stomach-protecting seasoning product | — | 2026-05-26 | — | — | CN | claimed |
| CN-122091626-A | Metal bipolar plate, preparation method thereof and fuel cell | — | 2026-05-26 | — | — | CN | claimed |
| EP-3785708-B1 | FILM-FORMING COMPOSITION CONTAINING SURFACTANT OR SURFACTANT AND SALT AS WHITENING AGENT | CAPSUGEL BELGIUM NV (BE) | 2026-05-20 | — | — | EP | claimed |
| CN-118479451-B | Method for synthesizing carbon cathode material of sodium battery in ultrafast way | 上海交通大学绍兴新能源与分子工程研究院 | 2026-05-19 | — | — | CN | claimed |
| WO-2026099254-A1 | WAFER FILLED WITH A FILLING COMPRISING A COATED FOOD ACID | ASTRA SWEETS (BE) | 2026-05-15 | — | — | WO | claimed |
| CN-119905535-B | Olivine sodium iron phosphate composite material and preparation method and application thereof | 四川易纳能新能源科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122039492-A | Cigarette paper coloring agent and preparation method thereof | 杭州市实业投资集团有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122031379-A | Fluorine Lei Lana-moxidectin nano drop containing penetration enhancer and preparation method thereof | 广州白云山宝神动物保健品有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122039148-A | Composite electrolytic water catalyst based on coal gangue carbon residue substrate and ligand intercalated layered double hydroxide and preparation method thereof | 安徽理工大学 | 2026-05-15 | — | — | CN | claimed |
| US-4772480-A | Method of controllingly aging edible material | YAMANE AKIYOSHI (JP) | 1988-09-20 | — | — | US | claimed |
| US-4581235-A | YEAST, AN EDIBLE ACID, A BUFFER A NITROGEN PRODUCING COMPOUND, ANDFLAVORINGS | Hoskins, George W. (CA) | 1986-04-08 | — | — | US | claimed |
| US-4506684-A | PRECIPITATION OF METAL SALTS | PHILIP MORRIS INCORPORATED (US) | 1985-03-26 | — | — | US | claimed |
| US-4406882-A | GLYCYRRHETINIC ACID, ESTER DERIVATIVES | BIOREX LABORATORIES LIMITED (GB) | 1983-09-27 | — | — | US | claimed |
| US-4213918-A | Process for producing clear aqueous solution of olefin sulfonic acid | THE LION FAT & OIL CO., LTD. (JP) | 1980-07-22 | — | — | US | claimed |
| US-4178213-A | Fermentation process for the production of (+)-2-(5β-n-butyl-4β-hydroxy-2-oxo-tetrahydrofuran-3β-yl)-2α-methylacetic acid | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-12-11 | — | — | US | claimed |
| US-4029606-A | ACYL-POLYHYDROXY CARBOXYLATE | LION FAT & OIL CO., LTD. (JA) | 1977-06-14 | — | — | US | claimed |
| US-4013416-A | Diagnostic means for the detection of protein in body fluids | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1977-03-22 | — | — | US | claimed |
| US-3971703-A | Method of detecting and counting bacteria | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1976-07-27 | — | — | US | claimed |
| US-3930896-A | NICKEL-COBALT ALLOY | TATSUTA DENSEN KABUSHIKI KAISHA (JA) | 1976-01-06 | — | — | US | claimed |