Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL28831630 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL123090 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL3408017 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL3408016 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL13570956 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL10884230 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL10943344 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL163975 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL9478602 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL16150497 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 578 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3691647-B1 | NEW TREATMENT OF SMA | HOFFMANN LA ROCHE (CH) | 2026-05-27 | — | — | EP | claimed |
| WO-2026099254-A1 | WAFER FILLED WITH A FILLING COMPRISING A COATED FOOD ACID | ASTRA SWEETS (BE) | 2026-05-15 | — | — | WO | claimed |
| EP-4740738-A1 | WAFER FILLED WITH A FILLING COMPRISING A COATED FOOD ACID | Astra Sweets (BE) | 2026-05-13 | — | — | EP | claimed |
| EP-4384142-B1 | MORDANT-FREE HAIR DYE CONTAINING PLANT DYES | HENKEL AG & CO KGAA (DE) | 2025-05-07 | — | — | EP | claimed |
| CN-118634360-A | Negative divalent or negative trivalent anion salt crosslinked frozen gel and preparation method and application thereof | 四川大学 | 2024-09-13 | — | — | CN | claimed |
| EP-4384142-A1 | MORDANT-FREE HAIR DYE CONTAINING PLANT DYES | Henkel AG & Co. KGaA (DE) | 2024-06-19 | — | — | EP | claimed |
| CN-115806478-B | Metal salt of hinokitiol, and preparation method and application thereof | 珠海市自然之旅生物技术有限公司 | 2024-06-14 | — | — | CN | claimed |
| CN-118064905-A | Electrolyte modification and electrolyte for prolonging service life of alkaline electrolyzed seawater electrode and application | 中国科学院大连化学物理研究所 | 2024-05-24 | — | — | CN | claimed |
| CN-117919251-A | Novel therapies for SMA | 豪夫迈·罗氏有限公司 | 2024-04-26 | — | — | CN | claimed |
| CN-117843818-A | Oxidation composition for dextrin oxidation and method for preparing carboxymaltodextrin | 金陵药业股份有限公司 | 2024-04-09 | — | — | CN | claimed |
| CN-1826145-A | Improved calcium phosphate bone cements | ORTUS MEDICAL LTD (GB) | 2006-08-30 | — | — | CN | claimed |
| EP-1633409-A1 | IMPROVED CALCIUM PHOSPHATE BONE CEMENTS | Ortus Medical Limited; (GB) | 2006-03-15 | — | — | EP | claimed |
| WO-2004103419-A1 | IMPROVED CALCIUM PHOSPHATE BONE CEMENTS | ORTUS MEDICAL LIMITED (a British Company of Needle Cottage) (GB) | 2004-12-02 | — | — | WO | claimed |
| US-5895525-A | ALKALI METAL MALATE OR CITRAMALATE SALT ACCELERATOR AND CALCIUM ALUMINUM SILICATE HYDRAULIC CEMENT; SHOTCRETING | MBT HOLDING AG (CH) | 1999-04-20 | — | — | US | claimed |
| US-5500668-A | INK JET PRINTING | XEROX CORPORATION (US) | 1996-03-19 | — | — | US | claimed |
| EP-0320213-B1 | Improved, controlled temperature process for making 2,2'-oxodisuccinates useful as laundry detergent builders | PROCTER & GAMBLE (US) | 1995-03-08 | — | — | EP | claimed |
| CN-1037171-A | Improved temperature control process for the preparation of 2, 2-oxodisuccinates as laundry detergent builders | PROCTER & GAMBLE (US) | 1989-11-15 | — | — | CN | claimed |
| EP-0320213-A2 | Improved, controlled temperature process for making 2,2'-oxodisuccinates useful as laundry detergent builders | THE PROCTER & GAMBLE COMPANY (US) | 1989-06-14 | — | — | EP | claimed |
| US-4798907-A | Controlled temperature process for making 2,2'-oxodisuccinates useful as laundry detergent builders | THE PROCTER & GAMBLE COMPANY (US) | 1989-01-17 | — | — | US | claimed |
| US-4720332-A | ZWITTERION, OXIDIZER | COFFEY BARRY W (US) | 1988-01-19 | — | — | US | claimed |