Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 6/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12311028 | 1.00 | GABRA1 (0.45) | GABRA1GABRG2GABRB3GABRB2ALDH1A1 | |
| SCHEMBL13681475 | 0.90 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRB2ALDH1A1 | |
| SCHEMBL13681556 | 0.84 | GABRA1 (0.43) | GABRA1GABRG2GABRB3GABRB2ALDH1A1 | |
| SCHEMBL17873493 | 0.81 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRB2ALDH1A1 | |
| SCHEMBL17873517 | 0.81 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRB2ALDH1A1 | |
| SCHEMBL17873491 | 0.81 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRB2ALDH1A1 | |
| SCHEMBL13681522 | 0.78 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRB2ALDH1A1 | |
| SCHEMBL13681568 | 0.77 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRB2ALDH1A1 | |
| SCHEMBL13681571 | 0.74 | PDE4A (0.49) | GABRA1GABRG2GABRB3GABRB2PDE4A | |
| SCHEMBL8422593 | 0.74 | PTGS1 (0.49) | ALDH1A1TP53CYP3A4TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026245-B2 | HIV replication inhibiting purine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-09-27 | — | — | US | disclosed |
| US-8026245-B2 | HIV replication inhibiting purine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-09-27 | — | — | US | disclosed |
| US-7923554-B2 | HIV inhibiting 1,2,4-triazin-6-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-04-12 | — | — | US | disclosed |
| US-7923554-B2 | HIV inhibiting 1,2,4-triazin-6-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-04-12 | — | — | US | disclosed |
| EP-1668011-B1 | HIV REPLICATION INHIBITING PURINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-02 | — | — | EP | disclosed |
| US-20090012092-A1 | Hiv Inhibiting 1,2,4-Triazin-6-One Derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-08 | — | — | US | disclosed |
| US-20090012092-A1 | Hiv Inhibiting 1,2,4-Triazin-6-One Derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012092-A1 | Hiv Inhibiting 1,2,4-Triazin-6-One Derivatives | NCOR1, NR1H3, NCOA3 | GABRA1 1960/4885GABRG2 3295/4885GABRB3 1131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.