Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 5/20 | 0.37 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | HTR7 | P34969 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | HTR3A | P46098 | 4/20 | 0.36 |
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 3/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL702541 | 0.74 | USP2 (0.43) | ALDH1A1 | |
| SCHEMBL13323857 | 0.71 | ITGB1 (0.36) | HTR6PRKDC | |
| SCHEMBL10664047 | 0.69 | JAK2 (0.47) | POLBALDH1A1JAK2TRPC5HTR1A | |
| SCHEMBL25616990 | 0.69 | POLB (0.65) | POLBALDH1A1TRPC5HTR1AHTR7 | |
| SCHEMBL24763862 | 0.66 | POLB (0.59) | POLBALDH1A1TRPC5TIPARP | |
| SCHEMBL5755960 | 0.64 | POLB (0.56) | POLBALDH1A1TRPC5 | |
| Hydrochloric Acid SCHEMBL29878858 | 0.63 | POLB (0.54) | POLBALDH1A1TRPC5 | |
| SCHEMBL31244835 | 0.63 | POLB (0.55) | POLBALDH1A1TRPC5HTR1AHTR7 | |
| SCHEMBL31244746 | 0.63 | TIPARP (0.65) | POLBALDH1A1TRPC5HTR1AHTR7 | |
| SCHEMBL31244613 | 0.63 | POLB (0.55) | POLBALDH1A1TRPC5HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2461811-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS USEFUL AGAINST VIRAL INFECTIONS, PARTICULARLY HCV | IDENIX Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | disclosed |
| WO-2011017389-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS USEFUL AGAINST VIRAL INFECTIONS, PARTICULARLY HCV | IDENIX PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2008019266-A2 | ACYCLIC, PYRIDAZINONE-DERIVED HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |
| WO-2008019303-A2 | PYRIDAZINONYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |