Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Edoxaban. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 known ✓ | P00742 | 20/20 | 1.00 |
| ▸ | F2 | P00734 | 2/20 | 1.00 |
| ▸ | F5 | P12259 | 1/20 | 1.00 |
| ▸ | PLAT | P00750 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Edoxaban SCHEMBL715418 | 1.00 | F10 (1.00) | F10F2F5PLAT | |
| Edoxaban SCHEMBL330046 | 1.00 | F10 (1.00) | F10F2F5PLAT | |
| Edoxaban SCHEMBL1504007 | 1.00 | F10 (1.00) | F10F2F5PLAT | |
| Edoxaban SCHEMBL715737 | 1.00 | F10 (1.00) | F10F2F5PLAT | |
| Edoxaban SCHEMBL1312016 | 1.00 | F10 (1.00) | F10F2F5PLAT | |
| Edoxaban SCHEMBL715818 | 1.00 | F10 (1.00) | F10F2F5PLAT | |
| Edoxaban SCHEMBL12833357 | 1.00 | F10 (1.00) | F10F2F5PLAT | |
| Edoxaban SCHEMBL16436967 | 1.00 | F10 (1.00) | F10F2F5PLAT | |
| Edoxaban SCHEMBL714523 | 1.00 | F10 (1.00) | F10F2F5PLAT | |
| Edoxaban SCHEMBL16543780 | 1.00 | F10 (1.00) | F10F2F5PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2548556-B1 | METHOD FOR IMPROVING DISSOLVABILITY OF ANTICOAGULANT | DAIICHI SANKYO CO LTD (JP) | 2016-08-10 | — | — | EP | disclosed |
| EP-2368870-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE CARBOXYLIC ACID | Daiichi Sankyo Company, Limited (JP) | 2011-09-28 | — | — | EP | disclosed |