Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6131064 | 0.81 | ABCG2 (0.53) | MEN1KMT2ACLK4CTSKNPC1 | |
| SCHEMBL30629328 | 0.81 | ABCG2 (0.49) | MEN1KMT2ACTSKNPC1XDH | |
| SCHEMBL16456300 | 0.79 | TNKS (0.58) | MEN1KMT2ADYRK1ACLK4LRRK2 | |
| SCHEMBL6508869 | 0.75 | MEN1 (0.82) | MEN1KMT2ACLK1NPC1SMN1; SMN2 | |
| SCHEMBL2666244 | 0.75 | MEN1 (0.59) | MEN1KMT2ACLK1CLK4NPC1 | |
| SCHEMBL20743783 | 0.74 | ABCG2 (0.36) | CLK4CTSKXDHABCG2USP30 | |
| SCHEMBL5670233 | 0.73 | ADORA1 (0.42) | MEN1KMT2ACTSKSMN1; SMN2ALDH1A1 | |
| SCHEMBL1186629 | 0.72 | — | — | |
| SCHEMBL28198548 | 0.72 | CYP2A6 (0.56) | KMT2ADYRK1ACLK4SMN1; SMN2ALDH1A1 | |
| SCHEMBL1232248 | 0.72 | CYP1A2 (0.55) | MEN1KMT2ACLK4CTSKNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462123-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | Schering Corporation (US) | 2012-06-13 | — | — | EP | disclosed |
| WO-2011017296-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2011-02-10 | — | — | WO | disclosed |