Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 20/20 | 0.45 |
| ▸ | AKT1 | P31749 | 18/20 | 0.45 |
| ▸ | AKT2 | P31751 | 18/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12323932 | 0.85 | AKT3 (0.49) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL8224462 | 0.80 | AKT3 (0.40) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL13959336 | 0.79 | MAPK1 (0.31) | — | |
| SCHEMBL8224200 | 0.77 | AKT3 (0.74) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL2261520 | 0.77 | AKT3 (0.74) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL2261527 | 0.77 | AKT3 (0.74) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL8225794 | 0.77 | AKT3 (0.43) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL8224124 | 0.77 | AKT1 (0.59) | AKT3AKT1AKT2 | |
| SCHEMBL8224355 | 0.76 | AKT3 (0.40) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL8223678 | 0.75 | AKT1 (0.40) | AKT3AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049500-B1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2011-09-07 | — | — | EP | disclosed |