Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 19/20 | 0.49 |
| ▸ | AKT1 | P31749 | 17/20 | 0.49 |
| ▸ | AKT2 | P31751 | 17/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218164 | 0.89 | AKT1 (0.44) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| SCHEMBL12323918 | 0.85 | AKT3 (0.45) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| SCHEMBL8225794 | 0.82 | AKT3 (0.43) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| SCHEMBL8226097 | 0.79 | AKT3 (0.55) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL8224462 | 0.79 | AKT3 (0.40) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| SCHEMBL8224124 | 0.79 | AKT1 (0.59) | AKT3AKT1AKT2 | |
| SCHEMBL8226943 | 0.78 | AKT3 (0.46) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL14304014 | 0.78 | AKT3 (0.54) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL12324605 | 0.78 | AKT3 (0.46) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| SCHEMBL8226862 | 0.77 | AKT3 (0.45) | AKT3AKT1AKT2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049500-B1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2011-09-07 | — | — | EP | disclosed |