Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11919044 | 0.89 | KMT2A (0.47) | KMT2ATSHRHRH3SMN1; SMN2SIGMAR1 | |
| SCHEMBL23384253 | 0.85 | KMT2A (0.47) | KMT2ATSHRHRH3SMN1; SMN2 | |
| SCHEMBL25881821 | 0.85 | TSHR (0.32) | KMT2ATSHRHRH3 | |
| SCHEMBL21909825 | 0.84 | TSHR (0.31) | KMT2ATSHRKDM4E | |
| SCHEMBL25075005 | 0.83 | MAPT (0.32) | KMT2AHRH3POLBSIGMAR1LMNA | |
| SCHEMBL26282856 | 0.83 | KMT2A (0.47) | KMT2ASMN1; SMN2SIGMAR1 | |
| SCHEMBL26280669 | 0.83 | KMT2A (0.47) | KMT2ASMN1; SMN2SIGMAR1 | |
| SCHEMBL26280673 | 0.83 | KMT2A (0.47) | KMT2ASMN1; SMN2SIGMAR1 | |
| SCHEMBL22828510 | 0.81 | KMT2A (0.44) | KMT2ATSHRHRH3LMNAKDM4E | |
| SCHEMBL24029454 | 0.81 | POLB (0.40) | KMT2AHRH3POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9290507-B2 | B-RAF kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-03-22 | — | — | US | disclosed |
| EP-2552907-B1 | PYRIDYLTRIAZOLES | BOEHRINGER INGELHEIM INT (DE) | 2014-10-22 | — | — | EP | disclosed |
| WO-2011117381-A1 | B-RAF KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-09-29 | — | — | WO | disclosed |