Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL962278 | 0.83 | MAPT (0.42) | MEN1POLBKMT2ACA12CA1 | |
| SCHEMBL26706541 | 0.79 | CA12 (0.41) | MEN1POLBKMT2ACA12CA1 | |
| SCHEMBL25218707 | 0.79 | CA12 (0.43) | MEN1POLBKMT2ACA12CA1 | |
| SCHEMBL27895720 | 0.77 | MEN1 (0.52) | MEN1POLBKMT2ACA12CA1 | |
| SCHEMBL2494291 | 0.77 | MEN1 (0.32) | MEN1POLBKMT2A | |
| SCHEMBL347715 | 0.75 | HRH3 (0.33) | MEN1POLBKMT2ACA12CA1 | |
| SCHEMBL8922179 | 0.75 | MEN1 (0.34) | MEN1POLBKMT2A | |
| SCHEMBL24588391 | 0.73 | CA12 (0.41) | CA12CA1CA2CA9CHRM2 | |
| SCHEMBL9705194 | 0.72 | MEN1 (0.52) | MEN1POLBKMT2ACHRM2CHRM1 | |
| SCHEMBL16188036 | 0.71 | MEN1 (0.42) | MEN1POLBKMT2ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366699-A1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2011-09-21 | — | — | EP | disclosed |