Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA1 | Q13131 | 9/20 | 0.77 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.77 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.67 |
| ▸ | KDR | P35968 | 11/20 | 0.63 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.61 |
| ▸ | EGFR | P00533 | 3/20 | 0.60 |
| ▸ | FLT3 | P36888 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12335816 | 0.93 | PRKAA1 (0.75) | PRKAA1PRKAA2LRRK2KDRTLK2 | |
| SCHEMBL18328648 | 0.92 | KDR (0.66) | PRKAA1PRKAA2LRRK2KDRTLK2 | |
| SCHEMBL15202708 | 0.88 | KDR (0.79) | PRKAA1PRKAA2LRRK2KDRTLK2 | |
| SCHEMBL28427292 | 0.87 | PRKAA1 (1.00) | PRKAA1PRKAA2LRRK2KDRTLK2 | |
| SCHEMBL2116298 | 0.87 | PRKAA1 (1.00) | PRKAA1PRKAA2LRRK2KDRTLK2 | |
| SCHEMBL29856752 | 0.87 | PRKAA1 (1.00) | PRKAA1PRKAA2LRRK2KDRTLK2 | |
| SCHEMBL12335933 | 0.86 | PRKAA1 (0.76) | PRKAA1PRKAA2LRRK2KDRTLK2 | |
| SCHEMBL15202712 | 0.85 | KDR (0.65) | PRKAA1PRKAA2LRRK2KDRTLK2 | |
| SCHEMBL12335811 | 0.85 | PRKAA1 (0.77) | PRKAA1PRKAA2LRRK2KDRTLK2 | |
| SCHEMBL12335812 | 0.85 | PRKAA1 (0.79) | PRKAA1PRKAA2LRRK2KDRTLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119777-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASE | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-09-29 | — | — | WO | disclosed |