Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2792275 | 0.86 | ESR2 (0.51) | CYP2D6NR1H2KCNH2NPC1RAB9A | |
| SCHEMBL2791379 | 0.84 | CYP2D6 (0.49) | CYP2D6NR1H2KCNH2NPC1RAB9A | |
| SCHEMBL2795487 | 0.83 | CYP2D6 (0.47) | CYP2D6NR1H2KCNH2NPC1RAB9A | |
| SCHEMBL2791858 | 0.82 | DRD2 (0.45) | GPR119CYP2D6NR1H2KCNH2NPC1 | |
| SCHEMBL2792129 | 0.81 | CYP2D6 (0.41) | CYP2D6NR1H2KCNH2NPC1RAB9A | |
| SCHEMBL2792130 | 0.81 | CYP2D6 (0.41) | CYP2D6NR1H2KCNH2NPC1RAB9A | |
| SCHEMBL2792914 | 0.80 | CYP2D6 (0.49) | CYP2D6KCNH2 | |
| SCHEMBL2792433 | 0.80 | CYP2D6 (0.44) | CYP2D6NR1H2KCNH2NPC1RAB9A | |
| SCHEMBL12311988 | 0.79 | PLG (0.58) | CYP2D6OPRM1PLGPLAUPLAT | |
| SCHEMBL2796125 | 0.79 | CYP2D6 (0.48) | CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263607-B2 | 1-substituted tetrahydroisoquinoline compound | ASTELLAS PHARMA INC. (JP) | 2012-09-11 | — | — | US | disclosed |
| US-20100168154-A1 | 1-SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168154-A1 | 1-SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND | CACNA1S, CACNA1E, CACNA1B | GPR119 409/4885CYP2D6 834/4885NR1H2 787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.