Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | POLA1 | P09884 | 1/20 | 0.51 |
| ▸ | POLG | P54098 | 1/20 | 0.51 |
| ▸ | HPRT1 | P00492 | 11/20 | 0.50 |
| ▸ | SERPINA3 | P01011 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17617329 | 0.92 | POLB (0.53) | POLBPOLA1POLGHPRT1MEN1 | |
| SCHEMBL17617646 | 0.92 | POLB (0.53) | POLBPOLA1POLGHPRT1MEN1 | |
| SCHEMBL14621723 | 0.92 | POLB (0.52) | POLBPOLA1POLGHPRT1MEN1 | |
| SCHEMBL17617327 | 0.90 | POLB (0.51) | POLBPOLA1POLGHPRT1MEN1 | |
| SCHEMBL17617645 | 0.90 | POLB (0.51) | POLBPOLA1POLGHPRT1MEN1 | |
| SCHEMBL18665426 | 0.89 | POLB (0.57) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL20067745 | 0.87 | HPRT1 (0.54) | HPRT1 | |
| SCHEMBL23346499 | 0.86 | POLB (0.54) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL12339258 | 0.84 | FGFR1 (0.53) | POLA1POLGSERPINA3 | |
| SCHEMBL21577310 | 0.84 | FGFR1 (0.53) | POLA1POLGSERPINA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268802-B2 | Anti-proliferative compounds, compositions, and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2012-09-18 | — | — | US | disclosed |