SCHEMBL20067745

SCHEMBL20067745

COC[C@@H](Cn1cnc2c(=O)[nH]c(N)nc21)OCP(=O)(N[C@@H](C)C(=O)OC(C)C)Oc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 19/20 0.54
PDE3A Q14432 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20067738 0.89 HPRT1 (0.55) HPRT1PDE3A
SCHEMBL12339253 0.87 POLB (0.53) HPRT1
SCHEMBL20067756 0.85 FAP (0.49)
SCHEMBL16066071 0.84 HPRT1 (0.63) HPRT1
SCHEMBL16062923 0.83 HPRT1 (0.59) HPRT1
SCHEMBL25574762 0.82 HPRT1 (0.50) HPRT1PDE3A
SCHEMBL20067744 0.80 FGFR1 (0.48)
SCHEMBL17617646 0.80 POLB (0.53) HPRT1
SCHEMBL17617329 0.80 POLB (0.53) HPRT1
SCHEMBL14621723 0.79 POLB (0.52) HPRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180105552-A1 NOVEL ANTIVIRAL COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND THEIR USE FOR TREATING VIRAL INFECTIONS KU LEUVEN RESEARCH & DEVELOPMENT (BE) 2018-04-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180105552-A1 NOVEL ANTIVIRAL COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND THEIR USE FOR TREATING VIRAL INFECTIONS TYMP, MTAP, PNP HPRT1 10/4885PDE3A 2374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.