SCHEMBL12341024

SCHEMBL12341024

CC(C)C1CCOC1C

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25971993 1.00
SCHEMBL25755633 1.00
SCHEMBL26657791 0.85 TRPA1 (0.35)
SCHEMBL26255085 0.85 TRPA1 (0.35)
SCHEMBL12150167 0.85 TRPA1 (0.31)
SCHEMBL17852570 0.83 TRPA1 (0.30)
SCHEMBL17852567 0.83 TRPA1 (0.30)
SCHEMBL22203215 0.80
SCHEMBL8166503 0.77
SCHEMBL8173406 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11826351-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY INC. (US) 2023-11-28 US disclosed
US-20230372298-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2023-11-23 US disclosed
US-20230276792-A1 SELECTIVE HERBICIDES BASED ON SUBSTITUTED ISOXAZOLIN CARBOXAMIDES AND CLOQUINTOCET-MEXYL BAYER AKTIENGESELLSCHAFT (DE) 2023-09-07 US disclosed
US-20230189808-A1 SELECTIVE HERBICIDES BASED ON SUBSTITUTED ISOXAZOLIN CARBOXAMIDES AND FURILAZOLE BAYER AKTIENGESELLSCHAFT (DE) 2023-06-22 US disclosed
US-20230174551-A1 CONDENSED ISOXAZOLINE DERIVATIVES AND THEIR USE AS HERBICIDES BASF SE (DE) 2023-06-08 US disclosed
US-20230148603-A1 DIOXAZOLINES AND THEIR USE AS HERBICIDES BASF SE (DE) 2023-05-18 US disclosed
US-20220062239-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2022-03-03 US disclosed
US-20210292312-A1 HERBICIDALLY ACTIVE 3-PHENYLISOXAZOLINE-5-CARBOXAMIDES OF TETRAHYDRO AND DIHYDROFURAN CARBOXYLIC ACIDS AND ESTERS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2021-09-23 US disclosed
US-20210093611-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2021-04-01 US disclosed
US-20200276162-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2020-09-03 US disclosed
US-10464905-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY INC. (US) 2019-11-05 US disclosed
US-20190000806-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2019-01-03 US disclosed
US-8268803-B2 5, 6-ring annulated indole derivatives and use thereof MERCK SHARP & DOHME CORP. (US) 2012-09-18 US disclosed
US-20100322901-A1 5, 6-RING ANNULATED INDOLE DERIVATIVES AND USE THEREOF SCHERING CORPORATION 2010-12-23 US disclosed
US-20100298303-A1 CGRP RECEPTOR ANTAGONISTS MERCK SHARP & DOHME CORP. (US) 2010-11-25 US disclosed
US-20100298303-A1 CGRP RECEPTOR ANTAGONISTS MERCK SHARP & DOHME CORP. (US) 2010-11-25 US disclosed
US-7282583-B2 Process for making 5,11-Dihydro-11-ethyl-5-methyl-8{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-10-16 US disclosed
US-20070129542-A1 Process for making 5,11-Dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2',3'-e][1,4]diazepin-6-one BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-06-07 US disclosed