Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | MYC | P01106 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PDE9A | O76083 | 1/20 | 0.30 |
| ▸ | IDH1 | O75874 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30468529 | 0.88 | PRKDC (0.42) | EGLN1IDO1SMN1; SMN2PRKDC | |
| SCHEMBL31369000 | 0.81 | EGLN1 (0.41) | EGLN1SMN1; SMN2PRKDCGRIN1GRIN2A | |
| SCHEMBL30276171 | 0.81 | PRKDC (0.43) | EGLN1SMN1; SMN2PRKDCKDM4EMYC | |
| SCHEMBL30276155 | 0.79 | PRKDC (0.42) | EGLN1SMN1; SMN2PRKDCKDM4E | |
| SCHEMBL30276207 | 0.77 | PRKDC (0.43) | EGLN1PRKDCKDM4EMYCIDH1 | |
| SCHEMBL30496839 | 0.75 | EGLN1 (0.42) | EGLN1IDO1PRKDCMYCMEN1 | |
| SCHEMBL30276209 | 0.75 | PRKDC (0.43) | EGLN1PRKDCKDM4EMYCMEN1 | |
| SCHEMBL38662097 | 0.75 | SLC6A4 (0.44) | EGLN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29891791 | 0.71 | OPRL1 (0.42) | EGLN1MEN1KMT2A | |
| SCHEMBL31261997 | 0.67 | EGLN1 (0.41) | EGLN1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280943-A1 | NEW SUBSTITUTED SPIROÝCYCLOALKYL-1,3'-INDOL¨-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS. | Almirall, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009124692-A1 | NEW SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS. | ALMIRALL, S.A. (ES) | 2009-10-15 | — | — | WO | disclosed |