Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL76810 | 0.83 | PARP1 (0.48) | PARP1 | |
| SCHEMBL30416453 | 0.82 | PARP1 (0.73) | PARP1 | |
| SCHEMBL77913 | 0.82 | PARP1 (0.73) | PARP1 | |
| SCHEMBL12342179 | 0.81 | PARP1 (0.58) | PARP1 | |
| SCHEMBL13095758 | 0.79 | PARP1 (0.67) | PARP1 | |
| SCHEMBL76831 | 0.79 | PARP1 (0.48) | PARP1 | |
| SCHEMBL2764528 | 0.79 | PARP1 (0.74) | PARP1 | |
| SCHEMBL12342215 | 0.78 | PARP1 (0.56) | PARP1 | |
| SCHEMBL12342182 | 0.77 | PARP1 (0.60) | PARP1 | |
| SCHEMBL3076203 | 0.77 | PARP1 (0.67) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268827-B2 | Pyridazinone derivatives as PARP inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA. (IT) | 2012-09-18 | — | — | US | disclosed |