Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12342182 | 0.86 | PARP1 (0.60) | PARP1 | |
| SCHEMBL12342215 | 0.85 | PARP1 (0.56) | PARP1 | |
| SCHEMBL12342191 | 0.79 | PARP1 (0.52) | PARP1 | |
| SCHEMBL4440359 | 0.79 | PARP1 (1.00) | PARP1 | |
| SCHEMBL20544497 | 0.78 | PARP1 (0.79) | PARP1 | |
| SCHEMBL4555554 | 0.77 | PARP1 (1.00) | PARP1 | |
| Trifluoroacetic Acid SCHEMBL4244891 | 0.76 | PARP1 (0.76) | PARP1 | |
| SCHEMBL4439534 | 0.73 | PARP1 (1.00) | PARP1 | |
| SCHEMBL4555570 | 0.72 | PARP1 (1.00) | PARP1 | |
| SCHEMBL26565113 | 0.72 | PARP1 (0.71) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261709-A1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | MSD ITALIA S.R.L. (IT) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261709-A1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | PARP1, PARP2, PARP3 | PARP1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.