Sugi Predict

Sugi Predict / Compounds / SCHEMBL12343554

SCHEMBL12343554

SCHEMBL12343554

CNC(=O)c1ccc(-c2cnc3[nH]nc(-c4ccccc4OC)c3c2)cc1F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAP4K1 Q92918 1/20 0.44
▸ AAK1 Q2M2I8 4/20 0.43
▸ AXL P30530 1/20 0.43
▸ HIF1A Q16665 1/20 0.42
▸ ALOX5AP P20292 1/20 0.42
▸ FEN1 P39748 1/20 0.42
▸ CAMKK2 Q96RR4 1/20 0.41
▸ ABL1 P00519 1/20 0.41
▸ CHEK1 O14757 1/20 0.40
▸ KIT P10721 1/20 0.40
▸ LRRK2 Q5S007 1/20 0.40
▸ ROCK2 O75116 2/20 0.39
▸ ROCK1 Q13464 2/20 0.39
▸ MET P08581 1/20 0.39
▸ BRAF P15056 1/20 0.39
▸ JAK2 O60674 1/20 0.38
▸ JAK1 P23458 1/20 0.38
▸ TYK2 P29597 1/20 0.38
▸ PDE4D Q08499 1/20 0.38
▸ PLK1 P53350 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12344635 0.88 MAP4K1 (0.47) MAP4K1AAK1CAMKK2ABL1CHEK1
SCHEMBL12343549 0.87 MAP4K1 (0.47) MAP4K1AAK1CAMKK2ABL1KIT
SCHEMBL3374253 0.85 HDAC6 (0.46) MAP4K1AAK1AXLCAMKK2ABL1
SCHEMBL12343551 0.83 CDK2 (0.43) MAP4K1HIF1A
SCHEMBL3489835 0.81 MAP4K1 (0.45) MAP4K1AAK1AXLHIF1AALOX5AP
SCHEMBL3489080 0.79 MAP4K1 (0.58) MAP4K1AAK1CAMKK2ABL1KIT
SCHEMBL12343552 0.79 DRD2 (0.41) MAP4K1
SCHEMBL3491552 0.79 MCHR1 (0.49) MAP4K1ABL1ROCK2ROCK1
SCHEMBL12343154 0.79 ABL1 (0.44) MAP4K1AAK1HIF1ACAMKK2ABL1
SCHEMBL12343157 0.79 ABL1 (0.44) MAP4K1AAK1AXLCAMKK2ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8268994-B2 Fused ring heterocycle kinase modulators SGX PHARMACEUTICALS, INC. (US) 2012-09-18 — — US disclosed
US-8268994-B2 Fused ring heterocycle kinase modulators SGX PHARMACEUTICALS, INC. (US) 2012-09-18 — — US disclosed
US-20100036118-A1 Fused Ring Heterocycle Kinase Modulators SGX PHARMACEUTICALS, INC. 2010-02-11 — — US disclosed
US-20100036118-A1 Fused Ring Heterocycle Kinase Modulators SGX PHARMACEUTICALS, INC. 2010-02-11 — — US disclosed
US-7626021-B2 Fused ring heterocycle kinase modulators SGX PHARMACEUTICALS, INC. (US) 2009-12-01 — — US disclosed
US-7626021-B2 Fused ring heterocycle kinase modulators SGX PHARMACEUTICALS, INC. (US) 2009-12-01 — — US disclosed
US-20070287711-A1 FUSED RING HETEROCYCLE KINASE MODULATORS SGX PHARMACEUTICALS, INC. (US) 2007-12-13 — — US disclosed
US-20070287711-A1 FUSED RING HETEROCYCLE KINASE MODULATORS SGX PHARMACEUTICALS, INC. (US) 2007-12-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070287711-A1 FUSED RING HETEROCYCLE KINASE MODULATORS MAP3K20, TTK, MAP3K19 MAP4K1 19/4885AAK1 187/4885AXL 556/4885
US-20100036118-A1 Fused Ring Heterocycle Kinase Modulators MAP3K20, TTK, MAP3K19 MAP4K1 19/4885AAK1 187/4885AXL 556/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.