Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.76 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886421 | 0.86 | KMT2A (1.00) | KMT2AMEN1NR4A2LMNASMN1; SMN2 | |
| SCHEMBL15557949 | 0.78 | KMT2A (0.67) | KMT2AMEN1NR4A2LMNASMN1; SMN2 | |
| SCHEMBL27958054 | 0.78 | MEN1 (0.83) | KMT2AMEN1NR4A2LMNASMN1; SMN2 | |
| SCHEMBL28207078 | 0.77 | KMT2A (0.76) | KMT2AMEN1NR4A2LMNASMN1; SMN2 | |
| SCHEMBL8600630 | 0.74 | MEN1 (0.72) | KMT2AMEN1NR4A2LMNASMN1; SMN2 | |
| SCHEMBL4784564 | 0.74 | MEN1 (0.72) | KMT2AMEN1LMNASMN1; SMN2PLK1 | |
| SCHEMBL17422835 | 0.73 | KMT2A (0.73) | KMT2AMEN1NR4A2LMNASMN1; SMN2 | |
| SCHEMBL2887226 | 0.73 | MEN1 (0.73) | KMT2AMEN1L3MBTL1POLB | |
| SCHEMBL1092934 | 0.72 | NR4A2 (1.00) | KMT2AMEN1NR4A2LMNASMN1; SMN2 | |
| SCHEMBL31621504 | 0.72 | NR4A2 (1.00) | KMT2AMEN1NR4A2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035429-B1 | FUSED [d]PYRIDAZIN-7-ONES | CEPHALON INC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2007149557-A1 | FUSED [d]PYRIDAZIN-7-ONES | CEPHALON, INC. (US) | 2007-12-27 | — | — | WO | disclosed |