Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 3/20 | 0.68 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 3/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1668736 | 1.00 | SPPL2A (0.68) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL469706 | 1.00 | SPPL2A (0.68) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL1548334 | 0.99 | SPPL2A (0.67) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL4608269 | 0.99 | SPPL2A (0.67) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL612336 | 0.99 | SPPL2A (0.67) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL6420306 | 0.99 | SPPL2A (0.67) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL746500 | 0.99 | SPPL2A (0.67) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28738354 | 0.94 | SPPL2A (0.59) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28738226 | 0.94 | SPPL2A (0.59) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28738224 | 0.94 | SPPL2A (0.59) | SPPL2APSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076513-B2 | Methods for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2011-12-13 | — | — | US | claimed |
| EP-2152667-B1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | TIBOTEC PHARM LTD (IE) | 2011-02-16 | — | — | EP | claimed |
| US-20100121094-A1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | TIBOTEC PHARMACEUTICALS LTD | 2010-05-13 | — | — | US | claimed |
| EP-2152667-A1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | Tibotec Pharmaceuticals (IE) | 2010-02-17 | — | — | EP | claimed |
| WO-2008132154-A1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-11-06 | — | — | WO | claimed |
| CN-101193857-A | Process and compound | NPIL PHARMACEUTICALS UK LTD (GB) | 2008-06-04 | — | — | CN | claimed |
| EP-1066276-B1 | PROCESS FOR THE SYNTHESIS OF HIV PROTEASE INHIBITORS | GLAXO GROUP LTD (GB) | 2003-06-11 | — | — | EP | claimed |
| CN-114230630-A | Triptolide derivative and application thereof | 郑州人民医院(郑州人民医院医疗管理中心) | 2022-03-25 | — | — | CN | disclosed |
| WO-2013011485-A1 | PROCESS FOR THE PREPARATION OF SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2013-01-24 | — | — | WO | disclosed |
| US-8076513-B2 | Methods for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2011-12-13 | — | — | US | disclosed |
| US-8076513-B2 | Methods for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2011-12-13 | — | — | US | disclosed |
| US-8076513-B2 | Methods for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2011-12-13 | — | — | US | disclosed |
| EP-2152667-B1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | TIBOTEC PHARM LTD (IE) | 2011-02-16 | — | — | EP | disclosed |
| EP-2152667-A1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | Tibotec Pharmaceuticals (IE) | 2010-02-17 | — | — | EP | disclosed |
| EP-2152667-A1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | Tibotec Pharmaceuticals (IE) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008132154-A1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-11-06 | — | — | WO | disclosed |
| WO-2008132154-A1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-11-06 | — | — | WO | disclosed |
| CN-101193857-A | Process and compound | NPIL PHARMACEUTICALS UK LTD (GB) | 2008-06-04 | — | — | CN | disclosed |
| EP-1893565-A1 | PROCESS AND COMPOUND | NPIL Pharmaceuticals (UK) Ltd (GB) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006131757-A1 | PROCESS AND COMPOUND | NPIL PHARMACEUTICALS (UK) LTD (GB) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121094-A1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | DNPEP, NPEPPS, ASNS | SPPL2A 1416/4885PSEN1 2365/4885PSEN2 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.