Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 6/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | ESR1 | P03372 | 3/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8410997 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1STSHSD17B1LMNA | |
| SCHEMBL12888958 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1STSHSD17B1LMNA | |
| SCHEMBL8410834 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1STSHSD17B1LMNA | |
| SCHEMBL1234798 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1STSHSD17B1LMNA | |
| SCHEMBL5156743 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1STSHSD17B1LMNA | |
| SCHEMBL1657651 | 0.90 | KDM4E (0.52) | KDM4EALDH1A1STSHSD17B1LMNA | |
| SCHEMBL12888942 | 0.87 | STS (0.47) | KDM4EALDH1A1STSHSD17B1ESR1 | |
| SCHEMBL1236119 | 0.87 | STS (0.47) | KDM4EALDH1A1STSHSD17B1ESR1 | |
| SCHEMBL1236122 | 0.87 | STS (0.47) | KDM4EALDH1A1STSHSD17B1ESR1 | |
| SCHEMBL8409267 | 0.87 | STS (0.51) | KDM4EALDH1A1STSHSD17B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893284-B2 | Oestrogen derivatives as inhibitors of steroid sulphatase | STERIX LIMITED (GB) | 2011-02-22 | — | — | US | disclosed |
| EP-1608671-B1 | OESTROGEN DERIVATIVES AS INHIBITORS OF STEROID SULPHATASE | STERIX LTD (GB) | 2010-01-06 | — | — | EP | disclosed |
| US-20060094696-A1 | Oestrogen derivatives as inhibitors of steroid sulphatase | STERIX LIMITED (GB) | 2006-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094696-A1 | Oestrogen derivatives as inhibitors of steroid sulphatase | HSD17B11, ESRRA, ESRRB | KDM4E 527/4885ALDH1A1 256/4885STS 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.