Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 6/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | ESR1 | P03372 | 3/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8410997 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1STSHSD17B1LMNA | |
| SCHEMBL1234797 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1STSHSD17B1LMNA | |
| SCHEMBL12888958 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1STSHSD17B1LMNA | |
| SCHEMBL8410834 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1STSHSD17B1LMNA | |
| SCHEMBL1234798 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1STSHSD17B1LMNA | |
| SCHEMBL1657651 | 0.90 | KDM4E (0.52) | KDM4EALDH1A1STSHSD17B1LMNA | |
| SCHEMBL12888942 | 0.87 | STS (0.47) | KDM4EALDH1A1STSHSD17B1ESR1 | |
| SCHEMBL1236119 | 0.87 | STS (0.47) | KDM4EALDH1A1STSHSD17B1ESR1 | |
| SCHEMBL1236122 | 0.87 | STS (0.47) | KDM4EALDH1A1STSHSD17B1ESR1 | |
| SCHEMBL8409267 | 0.87 | STS (0.51) | KDM4EALDH1A1STSHSD17B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1405860-B1 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use | STANFORD RES INST INT (US) | 2007-02-14 | — | — | EP | disclosed |
| EP-1405860-A1 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use | SRI INTERNATIONAL (US) | 2004-04-07 | — | — | EP | disclosed |
| US-6046186-A | ANTITUMOR AGENTS, ANTICARCINOGENIC AGENTS | SRI INTERNATIONAL (US) | 2000-04-04 | — | — | US | disclosed |
| WO-1999033858-A9 | ESTRONE SULFAMATE INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | STANFORD RES INST INT (US) | 1999-10-28 | — | — | WO | disclosed |