SCHEMBL12352148

SCHEMBL12352148

COc1cc2nc(-c3ccc(-c4nc5cc(C)c(C)cc5c(=O)o4)s3)oc(=O)c2cc1OC

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.65
MAPK1 P28482 1/20 0.65
KMT2A Q03164 2/20 0.62
MEN1 O00255 1/20 0.62
KLK7 P49862 9/20 0.56
KLK14 Q9P0G3 9/20 0.56
KLK5 Q9Y337 9/20 0.56
CTSG P08311 7/20 0.56
ALDH1A1 P00352 3/20 0.56
CTRC Q99895 2/20 0.56
HPGD P15428 2/20 0.56
MAPT P10636 1/20 0.56
PTK2B Q14289 1/20 0.56
KDM4E B2RXH2 4/20 0.50
POLB P06746 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.48
ELANE P08246 3/20 0.47
HTT P42858 1/20 0.47
NPC1 O15118 1/20 0.45
PRSS1 P07477 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12360752 0.94 HSD17B10 (0.72) HSD17B10MAPK1KMT2AMEN1KLK7
SCHEMBL914308 0.80 KMT2A (0.65) HSD17B10MAPK1KMT2AMEN1KLK7
SCHEMBL12907849 0.79 KMT2A (0.48) HSD17B10MAPK1KMT2AMEN1KLK7
SCHEMBL8068689 0.79 HSD17B10 (1.00) HSD17B10MAPK1KMT2AMEN1KLK7
SCHEMBL22952908 0.78 KLK7 (0.67) HSD17B10MAPK1KMT2AMEN1KLK7
SCHEMBL22272031 0.77 MEN1 (1.00) HSD17B10MAPK1KMT2AMEN1KLK7
SCHEMBL915062 0.76 KMT2A (0.64) HSD17B10MAPK1KMT2AMEN1KLK7
SCHEMBL8499615 0.75 KMT2A (0.70) HSD17B10MAPK1KMT2AMEN1KLK7
SCHEMBL12352140 0.74 KDM4E (0.71) HSD17B10MAPK1KMT2AMEN1ALDH1A1
SCHEMBL17554019 0.74 KLK7 (0.72) HSD17B10MAPK1KMT2AMEN1KLK7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8541488-B2 Formed resin article and polymer film FUJIFILM CORPORATION (JP) 2013-09-24 US disclosed
US-20110186791-A1 ULTRAVIOLET ABSORBENT COMPOSITION FUJIFILM CORPORATION (JP) 2011-08-04 US disclosed
US-20110163284-A1 LIGHTING UNIT COVER FUJIFILM CORPORATION (JP) 2011-07-07 US disclosed
US-20110092619-A1 FORMED RESIN ARTICLE AND POLYMER FILM FUJIFILM CORPORATION (JP) 2011-04-21 US disclosed
US-20110024701-A1 Ultraviolet Absorbent Composition FUJIFILM CORPORATION (JP) 2011-02-03 US disclosed