Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | HPGD | P15428 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | F2 | P00734 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | KLK7 | P49862 | 7/20 | 0.59 |
| ▸ | KLK14 | Q9P0G3 | 7/20 | 0.59 |
| ▸ | KLK5 | Q9Y337 | 7/20 | 0.59 |
| ▸ | CTSG | P08311 | 6/20 | 0.59 |
| ▸ | CTRC | Q99895 | 2/20 | 0.57 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.57 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12360752 | 0.84 | HSD17B10 (0.72) | HSD17B10MAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL8070379 | 0.84 | KDM4E (0.75) | HSD17B10MAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL8059761 | 0.84 | MAPK1 (0.72) | HSD17B10MAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL8068649 | 0.81 | HSD17B10 (0.69) | HSD17B10MAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL915806 | 0.80 | HSD17B10 (0.67) | HSD17B10MAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL8070396 | 0.80 | HSD17B10 (0.66) | HSD17B10MAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL8059748 | 0.80 | HSD17B10 (0.66) | HSD17B10MAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL22952908 | 0.79 | KLK7 (0.67) | HSD17B10MAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL913449 | 0.79 | ALDH1A1 (1.00) | HSD17B10MAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL8499615 | 0.79 | KMT2A (0.70) | HSD17B10MAPK1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150372-A | IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES; BLOCKING INTRACELLULAR SIGNAL TRANSDUCTION AND ACTIVATION OF TRANSCRIPTION FACTORS; KINASE INHIBITORS; ANTIARTHRITIC, ISCHEMIC AGENTS, MULTIPLE SCLEROSIS, TRANSPLANT REJECTION | SIGNAL PHARMACEUTICALS, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-5939421-A | TREATMENT OF IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS, TRANSPLANT REJECTION; INHIBIT KINASE(S) THAT REGULATE ACTIVATION OF TRANSCRIPTION FACTORS TO PREVENT PRODUCTION OF INFLAMMATORY PROTEINS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-17 | — | — | US | disclosed |
| WO-1999001441-A1 | QUINAZOLINE ANALOGS AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-01-14 | — | — | WO | disclosed |