Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9421106 | 0.79 | — | — | |
| SCHEMBL9421101 | 0.79 | — | — | |
| SCHEMBL9421065 | 0.76 | — | — | |
| SCHEMBL2748103 | 0.75 | HDAC1 (0.58) | — | |
| SCHEMBL2747705 | 0.74 | HDAC1 (0.42) | — | |
| SCHEMBL9421048 | 0.72 | HMGCR (0.33) | CYP2C9 | |
| SCHEMBL9421094 | 0.72 | — | — | |
| SCHEMBL6904056 | 0.71 | HTR2B (0.46) | CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL20773893 | 0.70 | LMNA (0.45) | CYP1A2CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL5902888 | 0.70 | SLC6A2 (0.47) | CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178577-B2 | Tricyclic derivatives as potent and selective histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-05-15 | — | — | US | disclosed |
| EP-2285376-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | Chipscreen Biosciences Ltd. (CN) | 2011-02-23 | — | — | EP | disclosed |
| US-20090292001-A1 | TRICYCLIC DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-11-26 | — | — | US | disclosed |
| WO-2009140164-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES LTD. (CN) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090292001-A1 | TRICYCLIC DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC10 | CYP1A2 3788/4885CYP2D6 4409/4885CYP2C9 4531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.