Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12355679 | 0.88 | CYP1A2 (0.50) | HTR2CHTR2BCYP1A2ADRA2AMAOA | |
| SCHEMBL2246016 | 0.83 | CYP1A2 (0.44) | HTR2CHTR2BCYP1A2ADRA2AMAOA | |
| SCHEMBL5582685 | 0.81 | MCHR1 (0.54) | HTR2CHTR2BCYP1A2ADRA2AMAOA | |
| SCHEMBL2250545 | 0.80 | CYP1A2 (0.46) | HTR2CHTR2BCYP1A2ADRA2AMAOA | |
| SCHEMBL8706424 | 0.80 | PPID (0.43) | HTR2CHTR2BCYP1A2ADRA2AMAOA | |
| SCHEMBL2246315 | 0.80 | CYP1A2 (0.54) | HTR2CHTR2BCYP1A2ADRA2AMAOA | |
| SCHEMBL8669883 | 0.77 | CA1 (0.60) | HTR2CHTR2BCYP1A2ADRA2AMAOA | |
| SCHEMBL8705209 | 0.77 | HTR2C (0.38) | HTR2CHTR2BCYP1A2ADRA2AMAOA | |
| SCHEMBL25086307 | 0.76 | HTR2C (0.50) | HTR2CHTR2BCYP1A2ADRA2AMAOA | |
| SCHEMBL2249768 | 0.76 | HTR2C (0.50) | HTR2CHTR2BCYP1A2ADRA2AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989451-B2 | Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments | AUCKLAND UNISERVICES LIMITED (NZ) | 2011-08-02 | — | — | US | disclosed |