Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 12/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12507091 | 0.86 | CHRM1 (0.37) | CHRM1CHRM2CHRM3CHRM4GPR119 | |
| SCHEMBL9936518 | 0.83 | CHRM1 (0.39) | CHRM1CHRM2CHRM3CHRM4GPR119 | |
| SCHEMBL2190026 | 0.83 | CHRM1 (0.54) | CHRM1CHRM2CHRM3CHRM4GPR119 | |
| SCHEMBL2190030 | 0.83 | CHRM1 (0.54) | CHRM1CHRM2CHRM3CHRM4GPR119 | |
| SCHEMBL857819 | 0.81 | CHRM1 (0.38) | CHRM1CHRM2CHRM3CHRM4GPR119 | |
| SCHEMBL11965220 | 0.79 | CHRM1 (0.38) | CHRM1CHRM2CHRM3CHRM4CHRM5 | |
| SCHEMBL4830125 | 0.79 | CHRM1 (0.47) | CHRM1CHRM2CHRM3CHRM4POLB | |
| SCHEMBL17572857 | 0.77 | CHRM1 (0.44) | CHRM1CHRM2CHRM3HSD11B1 | |
| SCHEMBL699340 | 0.76 | CHRM2 (0.38) | CHRM1CHRM2CHRM3CHRM4POLB | |
| SCHEMBL1116693 | 0.75 | KMT2A (0.47) | CHRM1CHRM2CHRM3CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994323-B2 | Chromen-2-one derivatives | NEUROSEARCH A/S (DK) | 2011-08-09 | — | — | US | disclosed |
| EP-2158200-B1 | NOVEL CHROMEN-2-ONE DERIVATIVES | NEUROSEARCH AS (DK) | 2011-07-13 | — | — | EP | disclosed |
| US-20100217002-A1 | NOVEL CHROMEN-2-ONE DERIVATIVES | NEUROSEARCH A/S (DK) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100217002-A1 | NOVEL CHROMEN-2-ONE DERIVATIVES | CBX2, CYP2J2, CDYL2 | CHRM1 630/4885CHRM2 677/4885CHRM3 606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.