SCHEMBL12357151

SCHEMBL12357151

CCCC1CCC(C2COC(C3CCC(c4cc(F)c(C(F)(F)Oc5cc(F)c(F)c(F)c5)c(F)c4)OC3)OC2)CC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16258042 0.90 FASN (0.33)
SCHEMBL13419356 0.89
SCHEMBL12561362 0.88
SCHEMBL18960019 0.88
SCHEMBL10027430 0.86
SCHEMBL12357148 0.84 FASN (0.32)
SCHEMBL10260199 0.84 FASN (0.32)
SCHEMBL16258071 0.84
SCHEMBL7729434 0.83 CYP2C9 (0.34)
SCHEMBL7729441 0.83 CYP2C9 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2351741-B1 PENTACYCLIC LIQUID CRYSTAL COMPOUND HAVING NITROGEN-CONTAINING HETEROCYCLIC RING, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORP (JP) 2016-11-30 EP disclosed
US-8475888-B2 Five-ring liquid crystal compound having a nitrogen-containing heterocyclic ring, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2013-07-02 US disclosed
US-8475888-B2 Five-ring liquid crystal compound having a nitrogen-containing heterocyclic ring, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2013-07-02 US disclosed
US-20110193022-A1 FIVE-RING LIQUID CRYSTAL COMPOUND HAVING A NITROGEN-CONTAINING HETEROCYCLIC RING, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2011-08-11 US disclosed
US-7951432-B2 Five-ring liquid crystal compound having cyclohexane ring, liquid crystal composition, and liquid crystal display device CHISSO CORPORATION (JP) 2011-05-31 US disclosed
US-7951433-B2 Five-ring liquid crystal compound having CF2O bonding group, liquid crystal composition, and liquid crystal display device CHISSO CORPORATION (JP) 2011-05-31 US disclosed
US-7951432-B2 Five-ring liquid crystal compound having cyclohexane ring, liquid crystal composition, and liquid crystal display device CHISSO CORPORATION (JP) 2011-05-31 US disclosed
US-20100127211-A1 FIVE-RING LIQUID CRYSTAL COMPOUND HAVING CF20 BONDING GROUP, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE CHISSO CORPORATION (JP) 2010-05-27 US disclosed
US-7674507-B2 Pyran-dioxane derivatives, and the use thereof in liquid-crystalline media MERCK PATENT GMBH (DE) 2010-03-09 US disclosed
US-20090302273-A1 FIVE-RING LIQUID CRYSTAL COMPOUND HAVING CYCLOHEXANE RING, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE CHISSO CORPORATION (JP) 2009-12-10 US disclosed
US-20090302273-A1 FIVE-RING LIQUID CRYSTAL COMPOUND HAVING CYCLOHEXANE RING, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE CHISSO CORPORATION (JP) 2009-12-10 US disclosed
US-20080193682-A1 Pyran-Dioxane Derivatives, and the Use Thereof in Liquid-Crystalline Media MERCK PATENT GMBH (DE) 2008-08-14 US disclosed