Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | PPP3CB | P16298 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11887172 | 0.93 | CTSB (0.39) | CTSBPPP3CBCYP3A4CTSS | |
| SCHEMBL12362359 | 0.92 | CTSB (0.39) | CTSBPPP3CBCYP3A4CTSS | |
| SCHEMBL12362386 | 0.91 | CTSB (0.39) | CTSBPPP3CBCYP3A4CTSS | |
| SCHEMBL998163 | 0.91 | CTSB (0.39) | CTSBPPP3CBCYP3A4CTSS | |
| SCHEMBL996322 | 0.90 | CTSB (0.39) | CTSBPPP3CBCYP3A4CTSS | |
| SCHEMBL8248728 | 0.90 | CTSB (0.39) | CTSBPPP3CBCYP3A4CTSS | |
| SCHEMBL13385446 | 0.89 | CTSB (0.42) | CTSBPPP3CBCYP3A4CTSS | |
| SCHEMBL8250301 | 0.89 | CTSB (0.42) | CTSBPPP3CBCYP3A4CTSS | |
| SCHEMBL8250201 | 0.87 | CTSB (0.35) | CTSBPPP3CBCYP3A4CTSS | |
| SCHEMBL12362361 | 0.86 | CTSB (0.36) | CTSBPPP3CBCYP3A4CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989471-B2 | Macrocyclic inhibitors of hepatitis C virus | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2011-08-02 | — | — | US | disclosed |
| US-20100240698-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS | JANSSEN SCIENCES IRELAND UC (IE) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240698-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS | CYP2B6, SRD5A1, NR5A2 | CTSB 4505/4885PPP3CB 2441/4885CYP3A4 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.