Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNG | P07510 | 1/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | CHRND | Q07001 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.32 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12359141 | 0.87 | ROCK2 (0.38) | KDM1AMAOBLPAR2ROCK2NPY5R | |
| SCHEMBL1794842 | 0.82 | TRPV1 (0.42) | CHRNA1CHRNGITGA5CHRNB1CHRNB2 | |
| SCHEMBL1796912 | 0.80 | CHRNA1 (0.39) | CHRNA1CHRNGITGA5CHRNB1CHRNB2 | |
| SCHEMBL1797611 | 0.80 | TRPV1 (0.50) | CHRNA1CHRNGITGA5CHRNB1CHRNB2 | |
| SCHEMBL1797327 | 0.80 | HCRTR1 (0.39) | CHRNA1CHRNGITGA5CHRNB1CHRNB2 | |
| SCHEMBL1796485 | 0.80 | TRPV1 (0.52) | KDM1ABRD4 | |
| SCHEMBL1799917 | 0.76 | TRPV1 (0.40) | CHRNA1CHRNGITGA5CHRNB1CHRNB2 | |
| SCHEMBL12653222 | 0.74 | ROCK2 (0.37) | KDM1AMAOBLPAR2ROCK2NPY5R | |
| SCHEMBL12653103 | 0.74 | MEN1 (0.57) | NPC1RAB9AKDM4EGLATP53 | |
| SCHEMBL12350593 | 0.74 | KDM1A (0.42) | KDM1AMAOBPDE10AROCK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | VRK1, VRK2, VIL1 | CHRNA1 513/4885CHRNG 2704/4885ITGA5 1139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.