Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | STAT3 | P40763 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 6/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14363385 | 0.91 | KCNMA1 (0.68) | KCNMA1ALDH1A1STAT3KDM4EPOLB | |
| SCHEMBL331767 | 0.87 | MAPT (0.59) | ALDH1A1KDM4ERXFP1POLBHSD17B10 | |
| SCHEMBL12368204 | 0.84 | MAPT (0.76) | KCNMA1KDM4ERXFP1POLBHSD17B10 | |
| SCHEMBL7765905 | 0.84 | MAPT (0.60) | KCNMA1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14363413 | 0.83 | MEN1 (0.62) | KCNMA1ALDH1A1KDM4EPOLBHSD17B10 | |
| SCHEMBL330396 | 0.83 | TMPRSS4 (0.59) | ALDH1A1CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL12368201 | 0.82 | HSD17B10 (0.65) | KCNMA1ALDH1A1STAT3KDM4EPOLB | |
| SCHEMBL14363387 | 0.82 | KCNMA1 (0.75) | KCNMA1ALDH1A1KDM4EPOLBHSD17B10 | |
| SCHEMBL330440 | 0.80 | HTT (0.56) | KCNMA1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12368184 | 0.80 | KMT2A (0.80) | KCNMA1ALDH1A1KDM4EPOLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989498-B2 | Immunosuppressants; autoimmune disease; organs transplantation; antiinflammatory agents; viricides; antiproliferative agents; antitumor, anticancer agents | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-02 | — | — | US | disclosed |
| US-7989498-B2 | Immunosuppressants; autoimmune disease; organs transplantation; antiinflammatory agents; viricides; antiproliferative agents; antitumor, anticancer agents | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-02 | — | — | US | disclosed |
| US-7915255-B2 | Metabolism-modulating agents and uses therefor | VERVA PHARMACEUTICALS PTY LTD (AU) | 2011-03-29 | — | — | US | disclosed |
| US-7915255-B2 | Metabolism-modulating agents and uses therefor | VERVA PHARMACEUTICALS PTY LTD (AU) | 2011-03-29 | — | — | US | disclosed |