Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 2/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 4/20 | 0.40 |
| ▸ | SIK1 | P57059 | 1/20 | 0.40 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.39 |
| ▸ | EGFR | P00533 | 5/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | STK26 | Q9P289 | 3/20 | 0.38 |
| ▸ | STK24 | Q9Y6E0 | 3/20 | 0.38 |
| ▸ | STK4 | Q13043 | 2/20 | 0.38 |
| ▸ | STK3 | Q13188 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 3/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12371660 | 0.90 | PRKCQ (0.46) | PRKCQPAK1SIK2SIK1SIK3 | |
| SCHEMBL12399676 | 0.89 | ALDH1A1 (0.36) | PRKCQPAK1SIK2SIK1SIK3 | |
| SCHEMBL12371727 | 0.87 | PRKCQ (0.49) | PRKCQPAK1SIK2SIK1SIK3 | |
| SCHEMBL12371654 | 0.85 | JAK2 (0.39) | PRKCQPAK1SIK2SIK1SIK3 | |
| SCHEMBL12371809 | 0.84 | STK17A (0.40) | SIK2STK26STK24STK4STK3 | |
| SCHEMBL12371797 | 0.84 | ALDH1A1 (0.43) | PRKCQADORA3ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL12371778 | 0.84 | HDAC3 (0.41) | SIK2SIK1SIK3FGFR1EGFR | |
| SCHEMBL2270517 | 0.83 | JAK2 (0.47) | PAK1SIK2SIK1SIK3FGFR1 | |
| SCHEMBL12371668 | 0.83 | JAK2 (0.45) | PRKCQPAK1FGFR1EGFRADORA3 | |
| SCHEMBL13608336 | 0.83 | PIK3CD (0.42) | PRKCQPAK1SIK2SIK1SIK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989459-B2 | Protein kinase C (PKC); rheumatoid arthritis, lupus, transplant rejection, asthma, inflammatory bowel disease, cancer and diabetes; for example, 2-(pyrrolidin-3-ylmethylamino)-9-(2-trifluoromethoxybenzyl)-7,8-dihydro-9H-purin-8-one | PHARMACOPEIA, LLC (US) | 2011-08-02 | — | — | US | disclosed |
| WO-2008143674-A1 | PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2008-11-27 | — | — | WO | disclosed |
| US-20080085909-A1 | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085909-A1 | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors | PRKCE, PRKCH, PRKCQ | PRKCQ 3/4885PAK1 150/4885SIK2 671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.