Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.73 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | F2 | P00734 | 1/20 | 0.57 |
| ▸ | PLG | P00747 | 1/20 | 0.57 |
| ▸ | ELANE | P08246 | 1/20 | 0.57 |
| ▸ | CTSG | P08311 | 1/20 | 0.57 |
| ▸ | CMA1 | P23946 | 1/20 | 0.57 |
| ▸ | CTRC | Q99895 | 1/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | EP300 | Q09472 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13783795 | 1.00 | ALDH1A1 (0.73) | ALDH1A1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1023519 | 1.00 | ALDH1A1 (0.73) | ALDH1A1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13291895 | 0.89 | ALDH1A1 (0.65) | ALDH1A1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3716740 | 0.85 | ALDH1A1 (0.93) | ALDH1A1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7829113 | 0.85 | ALDH1A1 (0.93) | ALDH1A1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6747735 | 0.85 | ALDH1A1 (1.00) | ALDH1A1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6747736 | 0.85 | ALDH1A1 (1.00) | ALDH1A1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5770320 | 0.85 | ALDH1A1 (0.69) | ALDH1A1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8383162 | 0.85 | ALDH1A1 (1.00) | ALDH1A1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3236740 | 0.85 | ALDH1A1 (0.69) | ALDH1A1TSHRSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008298-B2 | Pyrrolopyrazine kinase inhibitors | Roche Palo Alto (US) | 2011-08-30 | — | — | US | disclosed |
| US-8008298-B2 | Pyrrolopyrazine kinase inhibitors | Roche Palo Alto (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2010-10-21 | — | — | US | disclosed |
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2010-10-21 | — | — | US | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | SYK, ZAP70, TYK2 | ALDH1A1 4082/4885TSHR 1966/4885SMN1; SMN2 4777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.