Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10202420 | 0.98 | HRH3 (0.55) | HRH3KDM4EMEN1KMT2APOLB | |
| SCHEMBL12238264 | 0.94 | HRH3 (0.54) | HRH3KDM4EMEN1KMT2APOLB | |
| SCHEMBL21900557 | 0.93 | HRH3 (0.51) | HRH3KDM4EMEN1KMT2APOLB | |
| SCHEMBL22248703 | 0.92 | HRH3 (0.65) | HRH3KDM4EMEN1KMT2APOLB | |
| SCHEMBL22248702 | 0.90 | HRH3 (0.62) | HRH3KDM4EMEN1KMT2APOLB | |
| SCHEMBL14369400 | 0.89 | KDM4E (0.48) | HRH3KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1535647 | 0.88 | KDM4E (0.54) | HRH3KDM4EMEN1KMT2APOLB | |
| SCHEMBL20234326 | 0.86 | HRH3 (0.61) | HRH3KDM4EMEN1KMT2APOLB | |
| SCHEMBL23266158 | 0.85 | NR5A1 (0.61) | HRH3KDM4ELMNARAB9ANPC1 | |
| SCHEMBL12762363 | 0.85 | NR5A1 (0.61) | HRH3KDM4ELMNARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207741-A1 | Activation of the Renin-Angiotensin System (RAS) and Sudden Cardiac Death | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207741-A1 | Activation of the Renin-Angiotensin System (RAS) and Sudden Cardiac Death | GJA1, RASGRP1, RASGRP3 | HRH3 3104/4885KDM4E 3435/4885MEN1 4242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.