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Sugi Predict / Targets / GJA1

GJA1

Gap junction alpha-1 protein · P17302 · GJA1 on Sugi Atlas →

5,105 patent compounds predicted against GJA1, 4,201 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL971021 SCHEMBL971021 0.55 5/20
SCHEMBL971023 SCHEMBL971023 0.55 5/20
SCHEMBL6805976 SCHEMBL6805976 0.47 5/20
Amikacin Amikacin (SCHEMBL6262715) 0.46 4/20
SCHEMBL6667042 SCHEMBL6667042 0.47 3/20
Amikacin Amikacin (SCHEMBL1003907) 0.46 3/20
SCHEMBL7597560 SCHEMBL7597560 0.45 3/20
Amikacin Amikacin (SCHEMBL4284452) 0.40 3/20
Tobramycin Tobramycin (SCHEMBL1638351) 0.52 2/20
SCHEMBL5027888 SCHEMBL5027888 0.51 2/20
SCHEMBL5027889 SCHEMBL5027889 0.51 2/20
Tobramycin Tobramycin (SCHEMBL7025058) 0.51 2/20
SCHEMBL7172755 SCHEMBL7172755 0.47 2/20
Tobramycin Tobramycin (SCHEMBL3952941) 0.46 2/20
SCHEMBL260169 SCHEMBL260169 0.46 2/20
SCHEMBL264401 SCHEMBL264401 0.46 2/20
SCHEMBL1262725 SCHEMBL1262725 0.46 2/20
SCHEMBL5981855 SCHEMBL5981855 0.46 2/20
SCHEMBL4007928 SCHEMBL4007928 0.46 2/20
SCHEMBL4007932 SCHEMBL4007932 0.46 2/20

Clinical trials — most relevant to GJA1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Effect of Pre-operative Electrical Stimulation on Peripheral Nerve Regeneration. PHASE2/PHASE3COMPLETED
StereoTactic Arrhythmia Radiotherapy in the NetherLands no. 2 PHASE2RECRUITING
METFORMIN FOR ATRIAL FIBRILLATION PHASE2UNKNOWN
The Synapse Project PHASE2COMPLETED
Prevention of Preterm Delivery in Twin Pregnancies by 17 Alpha-hydroxyprogesterone Caproate PHASE2COMPLETED
MSC Exosome Therapy for Post-Preeclampsia Endothelial Dysfunction PHASE1/PHASE2RECRUITING
Open-label Study of SKY-GJB2 in Pediatric Subjects With GJB2-mediated Hearing Loss PHASE1/PHASE2RECRUITING
Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema PHASE2COMPLETED
Can E-cadherin Found in Tissue/Blood be Valuable in Identifying & Monitoring Patients With Post-proton Pump Inhibitor (PPI)-Responsive Heartburn PHASE1COMPLETED
Whole Heart Radiotherapy for End-stage Heart Failure PHASE1ENROLLING_BY_INVITATION
68Ga-PMD22 PET/CT Examination Targeting CLDN18.2 EARLY_PHASE1UNKNOWN
Cross-sectional and Prospective Study to Characterize Early-onset Presbycusis nanRECRUITING
Connexin Genotypes in Cystic Fibrosis nanUNKNOWN
Gap Junction Potentiation of Endothelial Function With Rotigaptide nanCOMPLETED
High Density Mapping in Brugada Syndrome nanCOMPLETED
Neuromuscular Transmission in Amyotrophic Lateral Sclerosis nanCOMPLETED
Functional Analysis by Dynamic Imaging of the Respiratory Epithelium in Infants With Cystic Fibrosis nanCOMPLETED
Typical and Atypical AVNRT High-resolution Mapping nanUNKNOWN
Variability of the Unique Fiber Potentials of a Spastic Muscle Treated With Botulinum Toxin nanCOMPLETED
Histological and Molecular Mechanisms of Pain in Patient With Chronic Pain From Adhesions nanCOMPLETED
Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients nanNOT_YET_RECRUITING
Evaluation of the Clinical Course of NERD and Assessment of the Esophageal Mucosa Resistance nanACTIVE_NOT_RECRUITING
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study nanCOMPLETED
Imaging of Endolymphatic Hydrops at 7T MRI nanRECRUITING
Targeting Potassium Channels to Reprogram Glioblastoma Microenvironment: in Vitro and in Vivo Studies nanUNKNOWN
Prognostic Value of FP-CIT-SPECT in Parkinson´s Disease nanCOMPLETED
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms nanUNKNOWN
Artificial Intelligence for the Prioritization of Genetic Background in Brugada Syndrome nanCOMPLETED
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting nanUNKNOWN
The Neuroprotective Effect of Dexmedetomidine Preserving Brain Functional Connectivity in Elderly Patients nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a GJA1 binder may also engage these)

ProteinNameSimilarity
Q6TYA8 — 1.000 Q6TYA8 →
P16863 — 1.000 P16863 →
P23242 — 1.000 P23242 →
Q4R4S7 — 1.000 Q4R4S7 →
Q29101 — 1.000 Q29101 →
P18246 — 1.000 P18246 →
P08050 — 1.000 P08050 →
Q6TYA7 — 1.000 Q6TYA7 →
Q6TYA9 — 0.999 Q6TYA9 →
A6XKM2 — 0.999 A6XKM2 →
P51914 — 0.999 P51914 →
O57474 — 0.998 O57474 →
P14154 — 0.998 P14154 →
Q6S9C0 — 0.998 Q6S9C0 →
P16864 — 0.996 P16864 →
Q0V990 — 0.995 Q0V990 →
P18860 — 0.994 P18860 →
Q7T047 — 0.994 Q7T047 →
P25305 — 0.993 P25305 →
Q02739 — 0.992 Q02739 →
O22757 — 0.992 O22757 →
O95377 — 0.991 O95377 →
Q9WUS4 — 0.991 Q9WUS4 →
P51916 — 0.991 P51916 →
P57773 — 0.991 P57773 →
Q92052 — 0.991 Q92052 →
O70610 — 0.991 O70610 →
P36383 — 0.990 P36383 →
P34672 — 0.990 P34672 →
Q64448 — 0.990 Q64448 →