Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | PKM | P14618 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2281148 | 0.87 | ALDH1A1 (0.56) | ALDH1A1PKMKMT2ATSHRMEN1 | |
| SCHEMBL17486850 | 0.79 | HRAS (0.60) | ALDH1A1KMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL1348621 | 0.78 | ATM (0.61) | ALDH1A1PKMKMT2ATSHRMEN1 | |
| SCHEMBL2788724 | 0.78 | PRMT1 (0.61) | ALDH1A1PKMKMT2ATSHRMEN1 | |
| SCHEMBL17486849 | 0.78 | GLRA3 (0.51) | ALDH1A1KMT2ATSHRMEN1LMNA | |
| SCHEMBL13181452 | 0.77 | ALDH1A1 (0.57) | ALDH1A1PKMKMT2ATSHRMEN1 | |
| SCHEMBL4617091 | 0.77 | MAPK1 (0.61) | ALDH1A1PKMKMT2ATSHRMEN1 | |
| SCHEMBL6567085 | 0.77 | MAPK1 (0.81) | ALDH1A1PKMKMT2ATSHRMEN1 | |
| SCHEMBL8403024 | 0.76 | MAPK1 (0.79) | ALDH1A1PKMKMT2ATSHRMEN1 | |
| SCHEMBL2277716 | 0.76 | ALDH1A1 (0.56) | ALDH1A1PKMKMT2ATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |