Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14514849 | 0.90 | MAPT (0.50) | MAOAMAOBMAPTKMT2AKDM4E | |
| SCHEMBL12374696 | 0.87 | KMT2A (0.52) | MAOAMAOBMAPTKMT2AMEN1 | |
| SCHEMBL14514847 | 0.83 | MAPT (0.54) | MAOAMAOBMAPTKMT2AKDM4E | |
| SCHEMBL12374862 | 0.83 | PADI4 (0.51) | MAOAMAOBMAPTKMT2AKDM4E | |
| SCHEMBL12374832 | 0.82 | MAOB (0.50) | MAOAMAOBMAPTKMT2AKDM4E | |
| SCHEMBL15233123 | 0.81 | MAOA (0.49) | MAOAMAOBMAPTKMT2AKDM4E | |
| SCHEMBL13818140 | 0.79 | MAOA (0.43) | MAOAMAOBMAPTKMT2AKDM4E | |
| SCHEMBL14514848 | 0.75 | MAPT (0.45) | MAOAMAOBMAPTKMT2AKDM4E | |
| SCHEMBL5599099 | 0.74 | CYP1A2 (0.61) | MAOAMAOBMAPTKMT2AKDM4E | |
| SCHEMBL5599097 | 0.74 | CYP1A2 (0.61) | MAOAMAOBMAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |