Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2280088 | 0.88 | PADI4 (0.48) | PADI4ALDH1A1RAB9ANPC1KDM4E | |
| SCHEMBL2280086 | 0.88 | PADI4 (0.48) | PADI4ALDH1A1RAB9ANPC1KDM4E | |
| SCHEMBL13818099 | 0.88 | PADI4 (0.38) | PADI4ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL13403311 | 0.81 | KDM4E (0.59) | ALDH1A1RAB9AKDM4ELMNAMAPT | |
| SCHEMBL12374830 | 0.81 | ABCG2 (0.36) | PADI4RAB9ANPC1KDM4EMAPT | |
| SCHEMBL2278736 | 0.79 | PADI4 (0.50) | PADI4ALDH1A1RAB9ANPC1KDM4E | |
| SCHEMBL2278731 | 0.79 | PADI4 (0.50) | PADI4ALDH1A1RAB9ANPC1KDM4E | |
| SCHEMBL2283097 | 0.79 | PADI4 (0.50) | PADI4RAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL2283091 | 0.79 | PADI4 (0.50) | PADI4RAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL4510109 | 0.77 | CYSLTR2 (0.44) | ALDH1A1SMN1; SMN2LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |